The artist is the granddaughter of Armenian immigrants to Argentina, since 1988 she lives in Berlin.
Her artistic work deals with issues related to the burden of national identity, the role of minorities in society and the potential of a space "in between." Der-Meguerditchian is interested in the impact of migration on the urban texture and its consequences. Reconstruction of the past and the building of archives are a red thread in her artistic research. Her work is multidisciplinary and uses different medias. Since 2010 she has been the Artistic Director of Houshamadyan, a project to reconstruct Ottoman Armenian town and village life. In 2014/15 she was awarded a fellowship at the Kulturakademie Tarabya, a residency program of the German Foreign Ministry and the Goethe Institute in Istanbul. Further, she participated in "Armenity,” the Pavilion awarded with the Golden Lion at the 56th Venice Biennial for the best national participation. Her work has been shown in many exhibitions around the world, including, among others, Germany, Argentina, the US and Turkey. Her last initiated and coordinated collective project "Grandchildren, new geographies of belonging" (DEPO Cultural Center- Istanbul) was supported by the Goethe Institut and the German Foreign Ministry in 2015. In 2018 she participated in Hello World Revising a Collection, a critical inquiry into the collection of the Nationalgalerie and its predominantly Western focus at the Hamburger Bahnhof in Berlin. Since 2014 she has worked with Women Mobilizing Memory. She is represented by Kalfayan Galleries in Athens.